Bifunctional crosslinking ligands for transthyretin
نویسندگان
چکیده
منابع مشابه
Bifunctional crosslinking ligands for transthyretin
Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosi...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2015
ISSN: 2046-2441
DOI: 10.1098/rsob.150105